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    • 戒断时间效应对海洛因成瘾大脑小世界网络影响的fMRI研究

    Jiajie CHEN,Yongbin LI,Xuan WEI,Jierong LIU,Jia ZHU, Wei LI,Qiang LI, Wei WANG

    Chinese Journal of Medical Imaging Technology（2017）

    Cited 6|Views13
    Abstract
    目的 探讨不同戒断时间对海洛因成瘾者大脑静息态下功能网络的影响.方法 16名强制戒断11～13个月的海洛因成瘾者(PA12组)、20名强制戒断5～7个月的海洛因成瘾者(PA6组)纳入静息态fMRI研究.运用图论理论构建小世界脑网络,比较两组海洛因成瘾者小世界特性及核心节点特性,分析核心节点与戒断时间的相关性.结果 两组脑网络均具有小世界特性(γ≈1、λ》1)且差异无统计学意义(P＞0.05);PA12组较PA6组脑网络的左侧中央前回及左侧海马旁回节点介数值降低,左侧楔叶、左侧颞极及右侧枕中回节点介数值升高(P均＜0.05).左侧中央前回(r=0.52,P=0.001)、左侧海马旁回(r=0.49,P=0.002)节点介数值均与戒断时间呈负相关,右侧枕中回节点介数值与戒断时间呈正相关(r=0.49,P=0.003).结论 戒断5～7个月后,海洛因成瘾者大脑网络小世界拓扑结构趋于稳定;长期戒断有助于降低成瘾者对毒品的相关记忆和潜在觅药行为,恢复视觉空间注意能力.
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    Key words
    Heroin dependence,Protracted abstinence,Magnetic resonance imaging
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