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Lung-Resident Memory Cd8 T Cells ( Trm) Are Indispensable for Optimal Crossprotection Against Pulmonary Virus Infection

Journal of leukocyte biology(2014)SCI 3区

Univ Connecticut

Cited 442|Views14
Abstract
ABSTRACT Previous studies have shown that some respiratory virus infections leave local populations of tissue TRM cells in the lungs which disappear as heterosubtypic immunity declines. The location of these TRM cells and their contribution to the protective CTL response have not been clearly defined. Here, fluorescence microscopy is used to show that some CD103+ TRM cells remain embedded in the walls of the large airways long after pulmonary immunization but are absent from systemically primed mice. Viral clearance from the lungs of the locally immunized mice precedes the development of a robust Teff response in the lungs. Whereas large numbers of virus-specific CTLs collect around the bronchial tree during viral clearance, there is little involvement of the remaining lung tissue. Much larger numbers of TEM cells enter the lungs of the systemically immunized animals but do not prevent extensive viral replication or damage to the alveoli. Together, these experiments show that virus-specific antibodies and TRM cells are both required for optimal heterosubtypic immunity, whereas circulating memory CD8 T cells do not substantially alter the course of disease.
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influenza virus,cellular immunity,fluorescence microscopy,immunization
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要点】:该论文揭示了肺常驻记忆CD8 T细胞(TRM)对于实现最优的交叉保护作用对抗肺部病毒感染的重要性,强调了这些细胞在局部免疫中的作用胜过循环记忆CD8 T细胞。

方法】:研究使用荧光显微镜技术追踪了CD103+ TRM细胞在肺大气道壁上的定位,并对比了局部免疫与系统性免疫小鼠的CTL响应。

实验】:通过实验观察了局部免疫小鼠和系统性免疫小鼠在病毒清除过程中的CTL分布及效果,使用的数据集名称未在摘要中明确提及,但实验结果表明局部免疫小鼠的肺内病毒清除先于Teff响应的发展,而系统性免疫小鼠的肺内TEM细胞数量虽多,却无法有效防止病毒复制或肺泡损伤。