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    • 腹腔注射PRE-084对PTSD大鼠额叶神经元损伤的影响

    Lei TONG,Li-li JI,Jun-bo PENG,Chang-hai FU,Zhen-yu WANG

    Progress of Anatomical Sciences（2017）

    Cited 0|Views7
    Abstract
    目的 探讨腹腔注射Sigma-1受体激动剂PRE-084对创伤后应激障碍(PTSD)大鼠额叶神经元损伤的影响.方法 利用单程长时应激(SPS)制备PTSD大鼠模型,将PTSD大鼠分为4组:vehicle、PRE-084、SPS+vehicle和SPS+ PRE-084组;连续注射PRE-084 7d后,取材各组大鼠额叶,利用免疫荧光染色检测各组大鼠额叶NeuN表达情况,免疫荧光染色、Western blot检测p-ERK蛋白表达情况.结果 免疫荧光染色结果显示,PTSD大鼠额叶神经元数量降低,腹腔注射PRE-084可以显著改善PTSD引起的神经元损伤;Western blot结果显示,PTSD大鼠额叶p-ERK表达水平降低,PRE-084可以显著升高p-ERK蛋白水平.结论 腹腔注射Sigma-1受体激动剂PRE-084改善PTSD大鼠额叶神经元损伤可能与上调ERK信号通路相关.
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    Key words
    PTSD,SPS,Sigma-1 receptor,neuron,ERK
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