他克莫司对特发性膜性肾病疗效的影响因素
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine（2019）
Abstract
目的:探讨他克莫司对特发性膜性肾病疗效的影响因素.方法:选取东莞东华医院2018年2月至11月收治的60例特发性膜性肾病患者,分为两组.对照组应用环磷酰胺治疗,观察组应用他克莫司治疗.比较两组患者治疗前后血浆白蛋白、尿蛋白、血清性激素指标.结果:治疗前,两组患者24 h尿蛋白定量与血浆白蛋白水平比较,差异无统计学意义(P＞0.05);治疗后,观察组患者的24 h尿蛋白定量与血浆白蛋白水平均优于对照组,差异具有统计学意义(P＜0.05).治疗前,两组患者的血清性激素水平比较,差异无统计学意义(P＞ 0.05);治疗后,观察组患者的睾酮(T)、雌二醇(E2)、黄体生成激素(LH)水平高于对照组,卵泡生成激素(FSH)水平低于对照组,差异具有统计学意义(P＜0.05).治疗过程中,在不良反应发生率方面,观察组患者的6.66％低于对照组的23.33％,差异具有统计学意义(P＜0.05).结论:对特发性肾病患者应用他克莫司与环磷酰胺治疗均有一定价值,但是他克莫司起效更快、治疗效果更佳,对性激素的影响比较小,能更好地改善患者生活水平,促进机体早日康复.
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