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黄精皂苷对糖尿病肾病大鼠肾损伤的保护作用及Wnt/β-catenin信号通路的影响

Chinese Traditional Patent Medicine(2019)

Cited 26|Views5
Abstract
目的 探讨黄精皂苷对糖尿病肾病大鼠肾损伤的保护作用及Wnt/β-catenin信号通路的影响.方法 采用单次腹腔注射大剂量链脲佐菌素(55 mg/kg)建立糖尿病肾病大鼠模型,并随机分为模型组,黄精皂苷低(35 mg/kg)、高(70 mg/kg)剂量组及厄贝沙坦(17.5 mg/kg)组,每组10只;另随机选取10只健康Wistar大鼠作为正常组,各组灌胃给药,1次/d,正常组及糖尿病肾病模型组灌胃等体积蒸馏水,给药时间为16周.检测各组大鼠一般状态、肾脏系数、尿素氮、血肌酐、24 h尿蛋白总量、肾脏组织病理形态变化、Ⅳ型胶原及Wnt4、β-catenin表达.结果 与模型组比较,黄精皂苷组大鼠一般状态及肾脏病理形态均得到一定程度改善;与模型组比较,黄精皂苷组大鼠肾脏系数,尿素氮、血肌酐及第8、12、16周的24 h尿蛋白总量明显减少(P<0.05);与模型组比较,黄精皂苷组大鼠Ⅳ型胶原及Wnt4、β-catenin表达均也明显降低(P<0.05).结论 黄精皂苷可以通过阻断Wnt/β-catenin信号通路的激活,抑制肾小管间质纤维化进程,最终发挥肾脏保护作用.
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