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不同炮制加工的熟地黄对雌性大鼠排卵功能的影响

Chinese Journal of Experimental Traditional Medical Formulae(2018)

Cited 13|Views4
Abstract
目的:探究不同炮制加工的熟地黄水煎液对雌性大鼠排卵功能的影响,为熟地黄的炮制加工与临床用药提供参考.方法:分别采用清蒸法(一蒸一晒)和传统法(九蒸九晒)炮制生地黄,得到2种不同炮制工艺的熟地黄.以动情周期正常的雌性成年大鼠为研究对象,设空白组和清蒸组、传统组.观察这2种熟地黄的水煎液对雌性大鼠动情周期、卵巢组织形态及血清激素水平的影响,清蒸组和传统组的给药剂量均为3.6 g·kg-1.建立熟地黄的HPLC指纹图谱,并结合药效学指标研究熟地黄对雌性大鼠排卵功能影响的差异.结果:与空白组比较,清蒸组大鼠血清中雌二醇和孕酮含量明显降低(P<0.05),动情周期明显延长(P<0.05),卵巢中闭锁卵泡数目明显升高(P<0.05);传统组各项指标变化皆不明显,与空白组相比无统计学差异.谱效学结果显示毛蕊花糖苷与清蒸法制备的熟地黄抑制大鼠排卵作用呈正相关;传统法制备的熟地黄HPLC图谱中3,5号峰与抑制排卵作用呈负相关.结论:清蒸法炮制的熟地黄对正常雌性大鼠的排卵有一定抑制作用,传统法炮制的熟地黄在排卵功能方面有一定优势.
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