老年肌少症与常见慢病共病的研究进展

Geriatrics & Health Care（2020）

Cited 5|Views97

Abstract

2010年欧洲老年人肌少症工作组(European Working Group on Sarcopenia in Older People,EWGSOP)颁布了肌少症共识,将肌肉减少症(肌少症,Sarcopenia)定义为进行性、广泛性骨骼肌质量减少和力量下降,以及由此引起的机体功能和生活质量降低甚至导致死亡的综合征[1].近10年来肌少症逐渐受到重视,EWGSOP于2018年对共识进行了更新.国际肌少症工作组和亚洲肌少症工作组也先后采用此定义,并发表了肌少症共识报告[2-3].尽管国内研究刚刚起步,缺少相关证据,中华医学会骨质疏松和骨矿盐疾病分会参照国际指南编撰了共识,强调了肌少症对器官功能有影响,引发心脏衰竭和呼吸衰竭,为老年人群致残和致死的主要原因之一[4].但是有关该病的临床特点以及与常见慢性病共病时的监测干预技术尚未达成共识.本文将肌少症相关进展做简要综述,以推动其防治工作的开展.

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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