动物转基因高效表达策略研究进展
Biotechnology Bulletin（2020）
Abstract
外源基因在动物体内、细胞内表达时,常由于各种原因导致基因沉默。目前,主要有两种策略用于打破该瓶颈:一是利用友好位点;二是优化外源基因顺式作用元件。利用友好位点就是通过定点整合技术将外源基因插入至活性转录区域;优化外源基因顺式作用元件即采用合适的启动子、增强子、内含子、染色质开放元件、核基质附着区等元件,构建出高效表达载体。对相关策略进行概述,为动物基因工程育种提供参考。
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