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Influence of Manganese Exposure on Cognitive Function, Plasma APP and Aβ Levels in Older Men.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY(2021)

Guangxi Med Univ

Cited 11|Views20
Abstract
Background: Elevated manganese (Mn) exposure impairs cognition in adults and children, but the association between Mn and cognitive function in elderly people is unclear. Previous studies have linked Mn neurotoxicity in AD to A beta-dependent mechanisms. However, the association between Mn and plasma APP and A beta in the general elderly population remains unknown. This study aimed to investigate the association between Mn exposure and cognitive function, plasma APP and plasma A in older adults. Methods: Cognitive abilities in 375 men aged 60 and older in Guangxi, China were assessed using the Mini-Mental State Examination (MMSE) and cognitive impairment were identified using education-stratified cut-off points of MMSE scores. Urinary Mn levels and plasma APP, and A beta levels were measured using ICP-MS and ELISA, respectively. Results: A total of 109 (29.07 %) older men were identified as having cognitive impairment. The median urinary Mn level was 0.22 mu g/g creatinine. Urinary Mn levels were negatively correlated with MMSE scores (beta = -1.35, 95 % CI: -2.65 to -0.06; p = 0.041). In addition, higher concentrations of urinary manganese were associated with a greater risk of cognitive impairment (OR - 2.03, 95 % CI: 1.14-3.59; comparing the highest and lowest manganese; p = 0.025). Moreover, plasma APP levels were inversely associated with urinary Mn levels (r = -0.123, p = 0.020), and positively associated with MMSE scores (r = 0.158, p = 0.002). Surprisingly, no correlations were observed between plasma A beta 42, A beta 40, A beta 40/A beta 42, or A beta 42/A beta 40 and urinary Mn levels and MMSE scores. Conclusion: These results suggested that Mn exposure is negatively associated with older men's cognition and plasma APP levels, but not plasma A beta levels.
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Key words
Urinary Mn,Plasma APP,Plasma A beta,Cognitive function,Older men
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