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Multi-omics Profiling of a CHO Cell Culture System Unravels the Effect of Culture Ph on Cell Growth, Antibody Titer, and Product Quality

Alison P. Lee,Yee Jiun Kok,Meiyappan Lakshmanan,Dawn Leong,Lu Zheng,Hsueh Lee Lim,Shuwen Chen,Shi Ya Mak,Kok Siong Ang,Neil Templeton,Taha Salim, Xiaona Wei, Eric Gifford,Andy Hee-Meng Tan,Xuezhi Bi,Say Kong Ng,Dong-Yup Lee,Wai Lam W. Ling,Ying Swan Ho

BIOTECHNOLOGY AND BIOENGINEERING（2021）

引用 16|浏览25
关键词
aggregation,charge variants,CHO cells,mAb quality attributes,multi-omics analysis,N-glycosylation,pH,systems biology
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