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    • Molecular and Cellular Characterization of Pyoderma Gangrenosum: Implications for the Use of Gene Expression.

    Alex G. Ortega-Loayza,Marcia A. Friedman,Ashley M. Reese,Yuangang Liu,Teri M. Greiling,Pamela B. Cassidy,Angelo V. Marzano,Lina Gao,Suzanne S. Fei,James T. Rosenbaum

    Journal of Investigative Dermatology（2022）

    Oregon Hlth & Sci Univ

    Cited 20|Views31
    Abstract
    Pyoderma gangrenosum (PG) is characterized by painful ulcers typically affecting the lower extremities. PG pathogenesis and triggers are poorly understood (Ortega-Loayza et al., 2018). Treatments target systemic inflammation, but clinical response and outcomes remain unpredictable. Further investigations are necessary to understand PG pathobiology; however, little is known about gene expression in PG, including whether important changes localize to the dermis or epidermis and whether nonlesional skin from patients with PG shows subclinical signs of the disease.
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    DPPG,HC,PG
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