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Astrocytic Reactivity Triggered by Defective Autophagy and Metabolic Failure Causes Neurotoxicity in Frontotemporal Dementia Type 3.

Abinaya Chandrasekaran,Katarina Stoklund Dittlau,Giulia Corsi,Henriette Haukedal,Nadezhda T. Doncheva,Sarayu Ramakrishna,Sheetal Ambardar,Claudia Salcedo,Sissel Schmidt,Yu Zhang,Susanna Cirera,Maria Pihl,Benjamin Schmid,Troels Tolstrup Nielsen,Jorgen E. Nielsen,Miriam Kolko,Julianna Kobolak,Andras Dinnyes,Poul Hyttel,Dasaradhi Palakodeti,Jan Gorodkin,Ravi S. Muddashetty,Morten Meyer,Blanca Aldana,Kristine K. Freude

Stem Cell Reports（2021）

Cited 26|Views54
Key words
CHMP2B,FTD3,hiPSC-derived astrocytes,autophagy,mitochondria,cytokines,reactive astrocytes,complement 3,NF-kB
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