Integrating Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity
Jeremy D Kratz,Shujah Rehman,Katherine A Johnson,Amani A Gillette,Aishwarya Sunil,Peter F Favreau,Cheri A Pasch,Devon Miller, Lucas C Zarling, Austin H Yeung,Linda Clipson,Samantha J Anderson, Alyssa K Steimle,Carley M Sprackling,Kayla K Lemmon,Daniel E Abbott,Mark E Burkard,Michael F Bassetti,Jens C Eickhoff,Eugene F Foley,Charles P Heise,Randall J Kimple,Elise H Lawson,Noelle K LoConte,Sam J Lubner,Daniel L Mulkerin,Kristina A Matkowskyj,Cristina B Sanger,Nataliya V Uboha,Sean J Mcilwain,Irene M Ong,Evie H Carchman,Melissa C Skala,Dustin A Deming Scientific reports（2025）
Key words
Organoids,Clonal heterogeneity,Colorectal cancer,Targeted therapy,EGFR
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