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    • Brain Functional Connectome Defines a Transdiagnostic Dimension Shared by Cognitive Function and Psychopathology in Preadolescents.

    Xiang Xiao, Christopher Hammond,Betty Jo Salmeron,Danni Wang,Hong Gu,Tianye Zhai,Hieu Nguyen,Hanbing Lu,Thomas J. Ross,Yihong Yang

    BIOLOGICAL PSYCHIATRY（2024）

    NIH | Johns Hopkins Univ

    Cited 3|Views23
    Abstract
    BACKGROUND: Cognitive function and general psychopathology are two important classes of human behavior dimensions that are individually related to mental disorders across diagnostic categories. However, whether these two transdiagnostic dimensions are linked to common or distinct brain networks that convey resilience or risk for the development of psychiatric disorders remains unclear. METHODS: The current study is a longitudinal investigation with 11,875 youths from the Adolescent Brain Cognitive Development (ABCD) Study at ages 9 to 10 years at the onset of the study. A machine learning approach based on canonical correlation analysis was used to identify latent dimensional associations of the resting -state functional connectome with multidomain behavioral assessments including cognitive functions and psychopathological measures. For the latent resting -state functional connectivity factor showing a robust behavioral association, its ability to predict psychiatric disorders was assessed using 2 -year follow-up data, and its genetic association was evaluated using twin data from the same cohort. RESULTS: A latent functional connectome pattern was identified that showed a strong and generalizable association with the multidomain behavioral assessments (5 -fold cross -validation: r = 0.68-0.73 for the training set [ n = 5096]; r = 0.56-0.58 for the test set [ n = 1476]). This functional connectome pattern was highly heritable ( h 2 = 74.42%, 95% CI: 56.76%-85.42%), exhibited a dose -response relationship with the cumulative number of psychiatric disorders assessed concurrently and at 2 years post-magnetic resonance imaging scan, and predicted the transition of diagnosis across disorders over the 2 -year follow-up period. CONCLUSIONS: These findings provide preliminary evidence for a transdiagnostic connectome-based measure that underlies individual differences in the development of psychiatric disorders during early adolescence.
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    Adolescence,Brain connectome,Cognitive function,Psychopathology,Transdiagnostic factor
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    【要点】：本研究发现了一个跨诊断维度的脑功能连接模式，该模式与认知功能和心理病理学行为维度相关，并在早期青春期预测精神疾病的发展。
    

    【方法】：研究采用基于典范相关分析的机器学习方法，分析静息态功能连接与多领域行为评估（包括认知功能和心理病理学测量）之间的潜在维度关联。
    

    【实验】：研究使用来自青少年大脑认知发展（ABCD）研究的11,875名9至10岁青少年的纵向数据，通过5倍交叉验证（训练集：r = 0.68-0.73，测试集：r = 0.56-0.58）识别出与行为评估强烈相关的一个潜在功能连接模式，并使用同一队列的双胞胎数据评估其遗传关联性。结果显示，该功能连接模式高度可遗传（h2 = 74.42%），与同时评估的以及磁共振成像后2年的累积精神疾病数量呈剂量-反应关系，并能预测2年随访期内诊断跨度的转变。
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