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    • 688P Gene Expression Profiling (GEP) Signatures Associated with Markers of Sensitivity to Immune and Angiogenic Therapy in Clear-Cell Renal Cell Carcinoma (ccrcc) with Sarcomatoid/rhabdoid Features

    P. M. Coelho Barata,S. Gulati,A. Elliott, A. Rao,E. F. Burgess,R. Mckay,H. J. Hammers, B. Gartrell, S. Darabi,M. A. Bilen,D. Geynisman,N. A. Dawson,K. Poorman,M. Zibelman,T. Zhang,S. Wei,W. M. Korn,C. Nabhan,C. J. Ryan,E. Heath

    Annals of Oncology（2021）SCI 1区

    Tulane Univ | UCCI Univ Cincinnati Canc Inst | Caris Life Sci | Univ Minnesota | Levine Canc Inst | Univ Calif San Diego | Univ Texas Southwestern Med Ctr Dallas | Montefiore Einstein Ctr Canc Care | Hoag Canc Ctr | Emory Univ | Fox Chase Canc Ctr | Georgetown Univ | Duke Univ | UCSF | Karmanos Canc Inst

    Cited 1|Views37
    Abstract
    Gene expression profiling studies have identified angiogenic and immune sig. with potential predictive value in patients (pts) with advanced ccRCC. We aimed to update the findings of a large multi-institutional genomics database (Barata, ASCO-GU 21), with a focus on tumors with sarcomatoid and rhabdoid features.
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    【要点】：本文更新了多机构基因组数据库中关于具有肉瘤样/横纹肌样特征的透明细胞肾细胞癌(ccRCC)患者中与免疫和血管生成治疗敏感性相关的688P基因表达谱(GEP)标记。
    

    【方法】：通过基因表达谱分析识别与angiogenic和immune信号相关的标记，这些标记可能对预测患者对治疗的敏感性有价值。
    

    【实验】：研究利用了一个大型的多机构基因组数据库（Barata, ASCO-GU 21），专注于具有肉瘤样和横纹肌样特征的肿瘤，但具体实验方法和数据集名称未在摘要中提及。