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Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process

Tao Wang,Eric M. Phillips,Stephen M. Dalby,Eric Sirota,Stephanus Axnanda,C. Scott Shultz, Pratiq Patel,Jacob H. Waldman,Embarek Alwedi,Xiao Wang,Kerstin Zawatzky, Matthew Chow, Nilusha Padivitage,Mark Weisel,Michael Whittington,Jianjun Duan, Taotao Lu

Organic Process Research & Development（2021）

Cited 30|Views2
Key words
fluorination,dynamic kinetic resolution,DKR,Noyori asymmetric reduction,single-pot direct isolation,through process
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