短期睡眠剥夺影响持续性注意力的认知神经机制:基于静息态功能MRI低频振幅分数分析
Radiologic Practice（2021）
Abstract
目的:基于静息态功能MRI,分析健康成人24 h睡眠剥夺前后大脑低频振幅分数(fALFF)的变化,探讨持续性注意力损伤的神经影像机制.方法:将50例健康志愿者纳入本研究,每例志愿者分别于正常睡眠(RW)及剥夺睡眠(SD)24 h后进行静息态fMRI扫描,采用精神运动警觉性任务(PVT)采集每例志愿者的持续性注意力行为学数据.使用DPABI平台和fALFF方法对2次静息态fMRI数据进行分析处理,并将志愿者在睡眠剥夺前、后的fALFF差值与执行PVT任务时脱漏(反应时间>500 ms)次数的差值(ALSD-ALRW)进行相关性分析.结果:24 h睡眠剥夺严重影响持续性注意力水平,睡眠剥夺后大脑fALFF有明显变化,表现为以背外侧前额叶为主的额顶网络区域的fALFF降低及以丘脑为主的皮层下灰质区域fALFF升高.RW和SD后PVT任务中脱漏数量的差值与颞中回fALFF的差值呈正相关(r=0.34,P=0.01),与背外侧额上回fALFF的差值呈负相关(r=-0.32,P=0.02).结论:额顶网络及丘脑等皮层下灰质区域自发神经活动的改变可能是睡眠剥夺后持续性注意力下降的重要神经机制.
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