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    • 应用光学相干断层扫描血管成像评估视网膜血流的可重复性及再现性

    刘旭阳,王婷婷,范梦杰,黄星星,朱益华,吴仁毅,樊宁,张达人, 高茹心

    Eye Science（2021）

    Cited 1|Views15
    Abstract
    目的:应用Cirrus HD-OCT 5000对正常眼黄斑及视盘血流参数进行血管成像测量,评估其可重复性及再现性.方法:纳入40只正常眼进行前瞻性研究.操作者A于一周内3天的同一时段(T1,T2,T3)对正常受试者的同一眼黄斑及视盘进行3次血管成像扫描,扫描过程中均开启FastTracTM图像跟踪功能,操作者B在T2时间点再次对受试者同一眼进行相同程序扫描,使用Angio Plex MetrixTM量化软件(版本10.0)自动测量黄斑和视盘的血管长度密度(vessel length density,VD)和血管灌注密度(vascular perfusion density,PD).应用单因素方差分析或非参数检验比较3次扫描的VD、PD是否有差异.采用组内相关系数(intraclass correlation coefficient,ICC)、变异系数(coefficient of variation,CV)评价操作者A的可重复性,采用一致性相关系数(consistent correlation coefficient,CCC)、重复性系数(repeatability coefficient,CR)、CV评价操作者间的再现性.结果:操作者A对黄斑及视盘各区域3次扫描的VD、PD之间差异无统计学意义(P>0.05).操作者A对黄斑和视盘VD、PD 3次扫描的ICC值分别为0.260～0.517、0.362～0.898,黄斑及视盘各区域VD、PD的CV值均<8.1％.黄斑和视盘VD、PD的操作者间CCC值分别为0.3130～0.5665、0.5149～0.7801;黄斑VD和PD的CR值分别为3.2212～4.6399、0.0574～0.0832;视盘VD和PD的CR值分别为2.0675～4.0630、0.0447～0.0730.黄斑CV值均<9.0％,视盘CV值均<6.9％.结论:非同日的同一时段视盘浅层血流参数具有较好的重复性及再现性,黄斑浅层血流参数的重复性及再现性相对较差.
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