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    • 肠道菌群通过短链脂肪酸参与过敏性哮喘发病的相关机制研究进展

    罗干,倪吉祥,杨玉婷,徐彪

    Shandong Medical Journal（2021）

    Cited 2|Views21
    Abstract
    过敏性哮喘是一种由多种细胞参与的,以可逆性气流受限和气道高反应性(AHR)为特点的气道慢性炎症性疾病.肠道菌群参与调节人体免疫反应,与哮喘的发病机制相关.短链脂肪酸(SCFAs)是肠道微生物群产生的一类信号分子,在多种疾病的发生、发展中发挥着重要作用.SCFAs可激活G蛋白耦联受体或ERK1/2信号通路,同时通过组蛋白乙酰化修饰等途径参与哮喘气道高反应性.阐述肠道菌群通过SCFAs参与过敏性哮喘发病的相关机制可为今后哮喘的防治提供新思路,从而更好地实现对相关疾病的精准治疗与个体化治疗.
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
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    Chat Paper
    【要点】：本文探讨了肠道菌群通过短链脂肪酸（SCFAs）参与过敏性哮喘发病机制的相关途径，为哮喘的防治提供了新思路。
    

    【方法】：研究采用文献分析的方法，系统梳理了肠道菌群、SCFAs与过敏性哮喘之间的关联。
    

    【实验】：未提及具体实验及数据集名称。