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反复玻璃体腔注射康柏西普或雷珠单抗对眼底血管性疾病患者角膜的影响

Journal of Shantou University Medical College(2021)

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Abstract
目的:探讨反复玻璃体腔注射康柏西普或雷珠单抗对眼底血管性疾病患者角膜的影响.方法:回顾性研究.选取2018年2月—2020年11月在汕头博德眼科医院接受治疗的眼底血管性疾病患者101例(101眼),其中男性61例,女性40例.按治疗药物不同分成康柏西普组(51例51眼)和雷珠单抗组(50例50眼).康柏西普组患者每月玻璃体腔注射康柏西普(0.5 mg/0.05 mL),雷珠单抗组患者每月玻璃体腔注射雷珠单抗(0.5 mg/0.05 mL),连续治疗3个月.分别于玻璃体腔注射前和注射后1、3、5个月检查患者的中央角膜厚度、角膜内皮细胞密度、六角形细胞比例、细胞面积变异系数等指标.结果:康柏西普组和雷珠单抗组患者的性别、年龄、疾病类型之间差异均没有统计学意义(P>0.05).两组患者接受注射治疗后1、3、5个月的术眼中央角膜厚度、角膜内皮细胞密度、六角形细胞比例、细胞面积变异系数等指标与治疗前比较,差异均没有统计学意义(P>0.05).结论:反复玻璃体腔注射康柏西普或雷珠单抗5个月内对眼底血管性疾病患者中央角膜厚度及角膜内皮细胞没有明显的影响.
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