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    • 直立不耐受儿童和青少年直立倾斜试验反应类型与多种维生素水平的关系

    王玉汶,林萍,张娟,王成,李芳,邹润梅,许毅

    Chinese Journal of Applied Clinical Pediatrics（2021）

    Cited 0|Views7
    Abstract
    目的:探讨直立不耐受儿童和青少年直立倾斜试验(HUTT)反应类型与多种维生素水平的关系。方法:选取2018年11月至2019年4月因晕厥、头晕、头痛、胸闷等直立不耐受症状为主诉，在中南大学湘雅二医院儿童医学中心就诊的儿童和青少年65例[男35例，女30例，年龄5～14(10.5±2.0)岁]，经病史询问、体格检查及必要的辅助检查，排除器质性心、脑血管疾病及其他系统疾病，根据HUTT结果分为HUTT阴性组和HUTT阳性组，比较2组患儿血清维生素A 1、B 1、B 2、B 6、B 9、B 12、C、E水平。计量资料采用独立样本 t检验，计数资料采用 χ2检验进行统计学分析。 结果:1．HUTT阴性组32例(男18例，女14例)，HUTT阳性组33例(男17例，女16例)，其中血管迷走性晕厥28例，体位性心动过速综合征5例。HUTT阴性组和HUTT阳性组年龄、男女比例和体质量指数比较差异均无统计学意义(均 P>0.05)。2.HUTT阳性组维生素B 1水平显著低于HUTT阴性组[(77.43±16.70) nmol/L比(88.56±18.98) nmol/L， t＝-2.513， P<0.05]，2组维生素A 1、B 2、B 6、B 9、B 12、C、E比较差异均无统计学意义(均 P>0.05)。 结论:HUTT阳性患儿存在维生素B 1水平相对不足，提示维生素B 1缺乏可能参与儿童和青少年神经介导性晕厥的发生。
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    Orthostatic intolerance,Head-up tilt test,Vitamin,Child,Adolescent
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：研究探讨了儿童和青少年中正立位倾斜试验（HUTT）反应类型与多种维生素水平之间的相关性，发现阳性HUTT组维生素 B1 水平显著低于阴性组，提示维生素 B1 在神经介导性晕厥的病理生理过程中可能起作用。
    

    【方法】：通过收集65例正立位不耐受症状的儿童和青少年，进行综合病史询问、体格检查和必要的实验室检测，排除心脏、脑血管等系统性疾病，然后根据HUTT结果将患者分为阴性组和阳性组，比较两组间维生素A1、B1、B2、B6、B9、B12、C和E的血清水平。
    

    【实验】：实验在2018年11月至2019年4月期间在儿童医学中心、中南大学第二湘雅医院进行，采用t检验分析连续数据，采用χ2检验分析分类数据，结果显示阳性HUTT组的维生素 B1 水平低于阴性组 [(77.43±16.70) nmol/L vs.(88.56±18.98) nmol/L]，而其他维生素水平在两组之间无显著差异。