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    • 抗菌药物的使用量与病原菌耐药性的相关性研究

    李春燕,汪可可,杨文伟,蒋良芝,吴亚洲

    Chinese Journal of Disinfection（2021）

    Cited 4|Views6
    Abstract
    目的 研究医院抗菌药物使用量与医院感染病原体耐药性之间的关系,为抗菌药物合理应用提供科学依据.方法 采用直线回归法,对某医院临床12种抗菌药物用药频度及其与病原菌的耐药性进行相关性分析.结果 该医院连续3年间多重耐药菌的检出率均呈波动趋势,用药频度也呈现波动状.在2016年该医院临床CRPA和CRE的检出率上升,而CRABA的检出率明显下降.2016年美洛培南、头孢吡肟、头孢哌酮/舒巴坦、左旋氧氟沙星的用药频度上升,而氨曲南明显降低.肺炎克雷伯菌对美罗培南、大肠埃希菌对头孢吡肟、肠杆菌属对头孢哌酮/舒巴坦、粪肠球菌对左旋氧氟沙星的耐药性与用药频度均呈正相关.结论 抗菌药物的用药频度与耐药菌的产生密切相关,加强抗菌药物的使用管理至关重要.
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    【要点】：本文研究了医院抗菌药物使用量与病原体耐药性之间的关系，发现用药频度与耐药性存在正相关，强调了加强抗菌药物使用管理的重要性。
    

    【方法】：采用直线回归法对某医院12种抗菌药物用药频度及其与病原菌耐药性进行相关性分析。
    

    【实验】：实验通过对某医院连续3年的数据进行研究，分析了12种抗菌药物的使用频度与多重耐药菌检出率的关系，数据集为该医院临床抗菌药物使用和病原体耐药性检测数据，结果显示肺炎克雷伯菌对美罗培南、大肠埃希菌对头孢吡肟等耐药性与用药频度正相关。