沙利度胺联合超声龈上洁治术治疗难治性复发性阿弗他溃疡的临床疗效
Chinese Journal of Clinical Rational Drug Use（2021）
Abstract
目的 观察沙利度胺片联合超声龈上洁治术治疗难治性复发性阿弗他溃疡(RAU)的临床疗效.方法 选择2018年10月-2019年9月就诊于宁夏医科大学总医院免疫系统异常的RAU患者58例,所有患者口腔内幽门螺旋杆菌感染阳性.根据治疗方法不同将患者分为病例组30例和对照组28例.对照组给予沙利度胺片治疗,病例组在此基础上局部使用超声龈上洁治术治疗,比较2组治疗后1个月、3个月、6个月的临床疗效,治疗前、治疗后1个月、3个月、6个月口腔内幽门螺旋杆菌感染情况,不良反应.结果 病例组患者治疗后1个月、3个月、6个月治疗总有效率分别为93.33％、90.00％、86.67％,高于对照组的67.86％、60.71％、53.57％,差异均有统计学意义(P<0.05);病例组患者治疗后1个月、3个月、6个月幽门螺杆菌感染阳性率均低于对照组,差异有统计学意义(P<0.05).结论 沙利度胺片联合超声龈上洁治术治疗RAU临床疗效较好,抗幽门螺旋杆菌感染可作为临床治疗RAU的一种有效手段.
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