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Enabling 5T4 for Targeted Cancer Therapy: TUB-030, a Novel ADC Built with Ethynylphosphonamidate Conjugation Chemistry, Shows Long-Lasting Anti-Tumor Activity Via Topoisomerase-I Inhibition with an Optimized Therapeutic Index

Saskia Schmitt,Isabelle Mai,Paul Machui,Sarah Herterich, Danila Hauswald,Philipp Ochtrop,Philipp Cyprys,Izabela Kozlowska, Annabel Kitowski,Marcus Gerlach, Olivier Marcq, Pamela A. Trail,Dominik Schumacher,Marc-Andre Kasper, Guenter Fingerle-Rowson, Bjorn Hock,Jonas Helma-Smets,Annette M. Vogl

Cancer Research（2024）

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