Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action
Ramulu Poddutoori,Kimberly Aardalen,Kiran Aithal, Sanjeev Surendranath Barahagar,Charamanna Belliappa,Mark Bock,Shekar Chelur,Andrea Gerken,Sreevalsam Gopinath,Bjoern Gruenenfelder,Michael Kiffe, Maithreyi Krishnaswami,John Langowski, Sudharshan Madapa,Kishore Narayanan,Chetan Pandit,Sunil Kumar Panigrahi,Mark Perrone, Ravi Kumar Potakamuri,Murali Ramachandra,Anuradha Ramanathan,Rita Ramos,Emine Sager,Susanta Samajdar,Hosahalli S. Subramanya, Devaraja Seethappa Thimmasandra,Eleni Venetsanakos,Henrik Mobitz JOURNAL OF MEDICINAL CHEMISTRY（2022）
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