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Double Knock-in Pig Models with Elements of Binary Tet-On and Phic31 Integrase Systems for Controllable and Switchable Gene Expression

Qin Jin,Xiaoyu Yang,Shixue Gou,Xiaoyi Liu,Zhenpeng Zhuang,Yanhui Liang,Hui Shi,Jiayuan Huang,Han Wu,Yu Zhao,Zhen Ouyang,Quanjun Zhang,Zhaoming Liu,Fangbing Chen,Weikai Ge,Jingke Xie,Nan Li,Chengdan Lai,Xiaozhu Zhao,Jiaowei Wang,Meng Lian,Lei Li,Longquan Quan,Yinghua Ye,Liangxue Lai,Kepin Wang

Science China Life Sciences（2022）

Cited 7|Views39
Key words
double knock-in,Tet-On system,phiC31-mediated cassette exchange,pig model,hKRASG12D-related tumorigenesis
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