AGP、AAT及HAP联合细胞因子检测在活动性肺结核中的诊疗价值
International Journal of Laboratory Medicine（2022）
Abstract
目的 探讨α1-酸性糖蛋白(AGP)、α1-抗胰蛋白酶(AAT)及触珠蛋白(HAP)联合细胞因子检测在活动性肺结核中的应用价值,为活动性肺结核的实验室诊断提供参考依据.方法 选取2020年3月至2021年3月昆明市第三人民医院收治的96例结核病患者为研究组,另选同期体检健康者83例作为对照组,比较两组AGP、AAT、HAP及细胞因子水平,评价其在活动性肺结核中的诊断价值.结果 与对照组比较,研究组患者血清中AGP、AAT、HAP、免疫球蛋白A(IgA)、白细胞介素-6(IL-6)、人γ干扰素(IFN-γ)的水平升高、肿瘤坏死因子-α(TNF-α)的水平降低,差异均有统计学意义(P<0.05);其余免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、白细胞介素-1(IL-1)等11种因子的水平在两组间比较差异无统计学意义(P>0.05).对两组差异有统计学意义的7种指标进行受试者工作特征曲线(ROC曲线)分析,结果显示,HAP、AGP、AAT、IgA、IL-6、IFN-γ、T N F-α诊断活动性肺结核的曲线下面积(A U C)分别为0.672、0.678、0.709、0.606、0.664、0.645、0.606,差异有统计学意义(P<0.05),AAT单独检测的诊断效能较高;IL-6+TNF-α 联合检测的诊断效能最高.Spearman相关分析显示,HAP与AGP、AGP与AAT、HAP与AAT之间均呈正相关(P<0.05).结论 HAP、AGP、AAT及IL-6、IFN-γ、TNF-α联合检测诊断活动性肺结核效能较高,值得临床推广应用.
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