急性白血病儿童髂骨骨髓的扩散加权成像与扩散张量成像研究

WANG Hong,FAN Guangming,NIE Hongfang,李方燕

Journal of Clinical Radiology（2022）

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Abstract

目的探讨扩散加权成像(DWI)及扩散张量成像(DTI)在儿童初发急性白血病髂骨骨髓浸润中的诊断价值.方法搜集36名健康儿童志愿者(对照组)及27例本院临床确诊初发急性白血病儿童(病例组)为研究对象,对照组按年龄划分为三组:A组(≤5岁),B组(5～10岁),C组(10～ 14岁),其中A组10例,B组15例,C组11例;病例组用同样的方法分组:A'组(≤5岁),B'组(5～10岁),C'组(10～14岁),其中A'组10例,B'组8例,C'组9例.采用GE Singna 1.5 T超导型磁共振扫描仪对所有受试者进行骨盆轴位扫描,扫描序列包括单次激发自旋回波-平面回波DWI (SS-SE-EPI-DWI)扫描序列(b=0,800 s/mm2)及单次激发自旋回波-平面回波DTI(SS-SE-EPI-DTI)扫描序列.原始图据传送到AW4.6工作站,应用Functool软件对图像数据进行后处理,在髂骨最大层面设置6个感兴趣区(ROI),分别测量表观扩散系数(ADC)值及各向异性分数(FA)值.对照组与病例组组间的ADC值及FA值的比较采用两独立样本t检验;绘制ADC值及FA值的受试者工作特征(ROC)曲线、并计算曲线下面积(AUC).结果对照组A组与病例组A'组间ADC值及FA值比较,差异均有统计学意义(t=2.653,P＜0.05;t=4.495,P＜0.001);对照组B组与病例组B'组间ADC值及FA值比较,差异均有统计学意义(t=4.604,P＜0.001;t-8.709,P＜0.001);对照组C组与病例组C'组间ADC值及FA值比较,其中ADC值差异无统计学意义(t=-1.958,P＞0.05),FA值差异有统计学意义(t=7.125,P＜0.001);ADC值的AUC为0.653(P =0.038);FA值的AUC为0.962(P =0.000).结论 FA值比ADC值敏感性更高,FA值与ADC值相比具有更高的诊断价值.可作为判断急性白血病骨髓浸润及严重程度的一项指标.

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance

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