粪菌移植在慢性肝病中应用的研究进展
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases（2022）
Abstract
粪菌移植(FMT)是一种将健康供体的肠道微生物菌群移植到患者肠道内,全面地调节患者肠道菌群的治疗方式,用于重建或恢复部分肠道菌群稳态[1].FMT作为重建肠道菌群的核心技术,除了针对肠道内疾病外,更多的研究投向了 FMT对肠道外疾病的潜在治疗价值.肠道菌群已成为慢性肝病发生发展的重要因素,肠道细菌和它们的代谢物可以通过门静脉进入肝脏并影响其生理.肠道菌群失调已经与多种慢性肝病有关,在慢性肝病病人中发现"肝-肠轴"被破坏的现象为证明肝脏影响肠道微生物的平衡提供了证据[2].本文综述了粪菌移植治疗慢性肝病的临床和基础研究进展.
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