Characterization and Clinical Correlation of the Immune Contexture in Intrahepatic Cholangiocarcinoma Using Multiplex Immunohistochemistry

Simon Peter,Valery Volk,Charlotte Hoffmann,Melanie Bathon,Benjamin Goeppert,Thomas Longerich,Thomas Albrecht,Tanja Reineke-Plaass,Friedrich Feuerhake,Arndt Vogel,Anna Saborowski

Journal of Hepatology（2022）

Hannover Med Sch | Univ Klinikum Heidelberg

Cited 0|Views36

Abstract

Eastern Mediterranean region and 114% in South-East Asia.HBV was the top cause of global liver cancer deaths (40%) in 2019, followed by HCV (29%) and alcohol (19%).NASH (APC: 0.35%) and alcohol (APC: 0.31%) had the fastest growing death ASRs between 1990 and 2019, while HCV grew at a slower rate (APC: 0.16%) and HBV declined (APC -0.30%).Conclusion: While the age-adjusted incidence and mortality rates have declined, the frequency of new cases, deaths and DALYs due to liver cancer has increased substantially between 1990 and 2019.The greatest rise in age adjusted liver cancer deaths occurred in the Americas and Europe and were driven by NASH and alcohol.Urgent measures are required to tackle the growing threat of NASH and alcohol-associated liver cancer.

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Pretraining has recently greatly promoted the development of natural language processing (NLP)
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【要点】：本论文使用多组免疫组织化学技术对肝内胆管癌的免疫微环境进行表征，并探讨其与临床参数的相关性。

【方法】：采用多组免疫组织化学技术对肝内胆管癌样本进行检测。

【实验】：研究结果显示，HBV和HCV是全球肝癌死亡的主要原因，NASH和酒精相关肝癌的死亡率在1990至2019年间显著增长，而HCV的增长率较低，HBV呈现下降趋势。