细胞自噬在银屑病中的作用及中药调控自噬研究进展
Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine（2022）
Abstract
银屑病是一种由免疫介导的慢性炎症性皮肤病,病理以角质形成细胞过度增殖、角化不全为其重要特征.自噬,指的是一类细胞的自我降解过程,将多余或受损的细胞器与蛋白质清除.如果在缺少细胞代谢能量的情况下,细胞采用自噬的方式,可以循环利用细胞内的成分,保持良好的自我稳态,维持基本的生存状态.在最近几年以来,许多研究结果显示,在许多免疫炎症性皮肤病中,均会产生细胞自噬变化的病理过程.一些治疗银屑病的药物也可以采用细胞自噬的方式,起到良好的治疗效果.经研究后发现,应用中草药进行治疗,可以对细胞自噬产生良好的调控作用.笔者通过概括近十余年来银屑病中自噬的国内外研究现状,为银屑病的治疗提供一个全新的方向,自噬可能成为治疗银屑病的一个新的靶点,中药诱导细胞自噬的研究将为治疗银屑病中药新药的研发提供新的方向.
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