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Homologous Recombination-Deficient Mutation Cluster in Tumor Suppressor RAD51C Identified by Comprehensive Analysis of Cancer Variants

Rohit Prakash,Yashpal Rawal,Meghan R. Sullivan,McKenzie K. Grundy,Helene Bret,Michael J. Mihalevic,Hayley L. Rein,Jared M. Baird,Kristie Darrah, Fang Zhang,Raymond Wang,Tiffany A. Traina,Marc R. Radke,Scott H. Kaufmann,Elizabeth M. Swisher,Raphael Guerois,Mauro Modesti,Patrick Sung,Maria Jasin,Kara A. Bernstein

Proceedings of the National Academy of Sciences（2022）

Cited 15|Views49

Key words

Homologous recombination,RAD51C,RAD51 paralog,DNA repair,Variants of unknown significance

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