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KaryoCreate: A CRISPR-based Technology to Study Chromosome-Specific Aneuploidy by Targeting Human Centromeres

Nazario Bosco,Aleah Goldberg,Xin Zhao,Joseph C. Mays,Pan Cheng,Adam F. Johnson,Joy J. Bianchi,Cecilia Toscani,Elena Di Tommaso,Lizabeth Katsnelson, Dania Annuar,Sally Mei, Roni E. Faitelson, Ilan Y. Pesselev, Kareem S. Mohamed,Angela Mermerian,Elaine M. Camacho-Hernandez, Courtney A. Gionco,Julie Manikas,Yi-Shuan Tseng,Zhengxi Sun, Somayeh Fani,Sarah Keegan,Scott M. Lippman,David Fenyo,Simona Giunta,Stefano Santaguida,Teresa Davoli

CELL（2023）

Cited 25|Views39

Key words

aneuploidy,centromere,chromosome gains and losses,kinetochore,DNA damage,mitosis,chromosome missegregation,CRISPR,cancer

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