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Non-specific Binding of Compounds in in Vitro Metabolism Assays: a Comparison of Microsomal and Hepatocyte Binding in Different Species and an Assessment of the Accuracy of Prediction Models

Iain Gardner,Mandy Xu, Chunyan Han,Yi Wang, Xingjin Jiao,Masoud Jamei,Hiba Khalidi,Peter Kilford,Sibylle Neuhoff, Roz Southall,David B. Turner,Helen Musther,Barry Jones,Simon Taylor

XENOBIOTICA（2022）

Cited 9|Views18
Key words
Non-specific binding predictions,free fraction,in vitro assays,liver microsomes,hepatocytes
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