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Bypassing Evolutionary Dead Ends and Switching the Rate-Limiting Step of a Human Immunotherapeutic Enzyme

John Blazeck,Christos S. Karamitros,Kyle Ford,Catrina Somody,Ahlam Qerqez,Kyle Murray,Nathaniel T. Burkholder,Nicholas Marshall,Anirudh Sivakumar,Wei-Cheng Lu,Bing Tan,Candice Lamb,Yuri Tanno,Menna Y. Siddiqui,Norah Ashoura,Silvia Coma,Xiaoyan M. Zhang,Karen McGovern,Yoichi Kumada,Yan Jessie Zhang,Mark Manfredi,Kenneth A. Johnson,Sheena D’Arcy,Everett Stone,George Georgiou

Nature Catalysis（2022）

Cited 12|Views44
Key words
Cancer metabolism,Enzyme mechanisms,Enzymes,Immunotherapy,Recombinant protein therapy,Catalysis
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