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Quantitative Assessment of the In-Vitro Binding Kinetics of Antisickling Aromatic Aldehydes with Hemoglobin A: A Universal HPLC-UV/Vis Method to Quantitate Schiff-base Adduct Formation

Xiaomeng Xu,Mohini S. Ghatge,Boshi Huang, Ahmed Alghamdi,Huiqun Wang,Daniel Pierce,Osheiza Abdulmalik,Yan Zhang,Martin K. Safo,Juergen Venitz

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS（2023）

Cited 1|Views18
Key words
Hemoglobin,Sickle cell disease,Allosteric effectors of hemoglobin,Antisickling,Universal method,Binding affinity and kinetics
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