HIV-1原发性耐药国内外研究进展
Journal of Modern Medicine & Health(2022)
Abstract
联合抗逆转录病毒治疗通过抑制患者体内人类免疫缺陷病毒(HIV)的复制,显著降低了HIV感染者/获得性免疫缺陷综合征患者病死率,延长了患者预期寿命.然而在抗病毒药物选择压力及病毒自身因素作用下HIV-1耐药突变不断产生.原发性耐药(PDR)对抗病毒治疗的疗效和患者远期预后具有负面影响.该文对近年来国内外PDR的研究进行了总结,旨在为后续相关研究提供思路,为PDR管理提供策略.
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