Rationale for the Selection of Dual Primary Endpoints in Prevention Studies of Cognitively Unimpaired Individuals at Genetic Risk for Developing Symptoms of Alzheimer's Disease.
Alzheimer s Research & Therapy（2023）
Key words
Alzheimer’s disease,Preclinical phase,Cognitively unimpaired,APOE genotype,Dual endpoints,Time to event,APCC,Model-informed drug development,Clinical trial simulation
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