2017～2021年陕西省实验动物使用单位SPF级大、小鼠质量监测结果分析与评估
wf（2023）
Abstract
目的 分析2017～2021年陕西省部分实验动物使用单位无特定病原体(specific pathogen free,SPF)级大、小鼠微生物和寄生虫质量检测结果,了解各单位大、小鼠病原微生物学质量状况,为实验动物质量管理与监测提供参考依据.方法 按照现行国家标准GB 14922.2-2011、GB/T 14926-2001和GB/T 14926.21-2008,由陕西省实验动物质量监督检测中心对大、小鼠进行病原微生物和寄生虫抽样检测并分析质量状况.结果 2017年～2021年累计抽检109家单位的小鼠2549只,45家单位的大鼠503只.检测结果显示,小鼠体外寄生虫(螨虫)检出率由5.26％降为0.15％,肠道鞭毛虫由10.53％降为0.45％,肠道蠕虫由0.40％升至2.39％,沙门菌由2.78％降至无检出,泰泽病原体抗体阳性率由1.38％降至无检出;大鼠体外寄生虫(螨虫)检出率由7.07％降至无检出;肠道鞭毛虫由11.50％降为0.83％,蠕虫由3.79％升至7.50％,金黄色葡萄球菌由1.77％降至无检出.小鼠病毒血清抗体阳性率,2017年检出小鼠肝炎病毒(4.71％)、仙台病毒(1.39％)和小鼠细小病毒(2.22％),2021年出小鼠肝炎病毒(0.30％)和仙台病毒(0.15％),小鼠肺炎病毒阳性率则由1.11％升至2.39％,小鼠呼肠孤病毒Ⅲ型由0.17％升至0.45％.大鼠仙台病毒阳性率由7.07％降为0.83％,大鼠细小病毒和大鼠冠状病毒仅2017年和2018年在个别单位有检出,大鼠肺炎病毒则由0.88％增长为10.00％.结论 近5年的检测结果表明,陕西省实验动物使用单位的大、小鼠病原微生物质量逐年提升,但仍存在一定问题,应持续采取严格的生物安全防控措施,加强动物实验过程,确保各单位在实验周期内动物质量合格.
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