A Rapid Theta Network Mechanism for Flexible Information Encoding

Elizabeth L. Johnson,Jack J. Lin,David King-Stephens,Peter B. Weber,Kenneth D. Laxer,Ignacio Saez,Fady Girgis,Mark D’Esposito,Robert T. Knight,David Badre

Nature Communications（2023）

Departments of Medical Social Sciences and Pediatrics | Department of Neurology and Center for Mind and Brain | Department of Neurology and Neurosurgery | Department of Neurological Surgery | Helen Wills Neuroscience Institute and Department of Psychology | Department of Cognitive

Cited 5|Views6

Abstract

Flexible behavior requires gating mechanisms that encode only task-relevant information in working memory. Extant literature supports a theoretical division of labor whereby lateral frontoparietal interactions underlie information maintenance and the striatum enacts the gate. Here, we reveal neocortical gating mechanisms in intracranial EEG patients by identifying rapid, within-trial changes in regional and inter-regional activities that predict subsequent behavioral outputs. Results first demonstrate information accumulation mechanisms that extend prior fMRI (i.e., regional high-frequency activity) and EEG evidence (inter-regional theta synchrony) of distributed neocortical networks in working memory. Second, results demonstrate that rapid changes in theta synchrony, reflected in changing patterns of default mode network connectivity, support filtering. Graph theoretical analyses further linked filtering in task-relevant information and filtering out irrelevant information to dorsal and ventral attention networks, respectively. Results establish a rapid neocortical theta network mechanism for flexible information encoding, a role previously attributed to the striatum.

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Key words

Cognitive control,Cortex,Human behaviour,Working memory,Science,Humanities and Social Sciences,multidisciplinary

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