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Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

Zenichi Ikeda,Taku Kamei,Yusuke Sasaki,Matthew Reynolds,Nozomu Sakai,Masato Yoshikawa,Michiko Tawada,Nao Morishita,Douglas R. Dougan, Chien-Hung Chen,Irena Levin,Hua Zou,Masako Kuno,Naoto Arimura, Yusuke Kikukawa,Mitsuyo Kondo,Kimio Tohyama,Kenjiro Sato

JOURNAL OF MEDICINAL CHEMISTRY（2023）

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