纳米载体的放射性核素标记方法研究进展
International Journal of Radiation Medicine and Nuclear Medicine（2023）
Abstract
基于纳米医学策略改善放射性核素递送效率、提高获取病灶信息的灵敏度和肿瘤治疗疗效已成为当今研究的热点。虽然不同类型的纳米载体已被用作放射性示踪剂，但放射性标记仍然是一个关键步骤。为确保放射性核素标记的标记率和稳定性，根据纳米载体类型、放射性核素和反应条件选取最合适的放射性标记策略是至关重要的。笔者主要综述了目前有螯合剂和无螯合剂两大类放射性核素的标记策略及其优缺点，以期为放射性核素标记不同纳米载体进行核素诊疗提供帮助。
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Key words
Radioisotopes,Nanoconjugates,Isotope labeling
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