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Abstract P4-08-02: LOXO-783: A Potent, Highly Mutant Selective and Brain-Penetrant Allosteric PI3Kα H1047R Inhibitor in Combination with Standard of Care (SOC) Treatments in Preclinical PI3Kα H1047R-mutant Breast Cancer Models

Loredana Puca,Michele S. Dowless, Carmen M. Perez-Ferreiro,Maria Jesus Ortiz-Ruiz,Gregory P. Donoho,Andrew Capen,Lysiane Huber,Sarah M. Bogner, Dongling Fei,Jason R. Manro,Chun Ping Yu, Wei Guo Xu,Rui Wang,Shuang Chen,Mark A. Hicks,Parisa Zolfaghari,Andrew Faber,Raymond Gilmour, Monica D. Ramstetter,Matthew T. Chang,Maria Jose Lallena,Xuequian Gong,David M. Hyman,Lillian M. Smyth,Barbara J. Brandhuber,Barry S. Taylor,Anke Klippel

Cancer Research（2023）

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