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Dyslipidemia in Diffuse Large B Cell Lymphoma Based on the Genetic Subtypes: a Single-Center Study of 259 Chinese Patients

Frontiers in oncology(2023)SCI 3区

Zhejiang Univ

Cited 0|Views25
Abstract
Background:Diffuse large B-cell lymphoma (DLBCL) is a kind of highly heterogeneous non-Hodgkin lymphoma, both in clinical and genetic terms. DLBCL is admittedly categorized into six subtypes by genetics, which contain MCD, BN2, EZB, N1, ST2, and A53. Dyslipidemia is relevant to a multitude of solid tumors and has recently been reported to be associated with hematologic malignancies. We aim to present a retrospective study investigating dyslipidemia in DLBCL based on the molecular subtypes.Results:This study concluded that 259 patients with newly diagnosed DLBCL and their biopsy specimens were available for molecular typing. Results show that the incidence of dyslipidemia (87.0%, p <0.001) is higher in the EZB subtype than in others, especially hypertriglyceridemia (78.3%, p = 0.001) in the EZB subtype. Based on the pathological gene-sequencing, patients with BCL2 gene fusion mutation are significantly correlative with hyperlipidemia (76.5%, p = 0.006) and hypertriglyceridemia (88.2%, p = 0.002). Nevertheless, the occurrence of dyslipidemia has no remarkable influence on prognosis.Conclusion:In summary, dyslipidemia correlates with genetic heterogeneity in DLBCL without having a significant influence on survival. This research first connects lipids and genetic subtypes in DLBCL.
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diffuse large B-cell lymphoma,molecular typing,dyslipidemia,hypertriglyceridemia,BN2 subtype,MCD subtype,EZB subtype,A53 subtype
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要点:本文针对分子亚型,调查了DLBCL患者的血脂失调,发现EZB亚型的发生率最高,特别是高三酰甘油血症。并且发现BCL2基因融合突变的患者明显与高脂血症和高三酰甘油血症相关。

方法:对259位中国患者的活检标本进行分子亚型技术诊断,统计分析其血脂情况。

实验:本文使用的数据集为259位DLBCL患者的病理标本,结果发现EZB亚型的患者血脂异常发生率最高,特别是高三酰甘油血症。BCL2基因融合突变的患者明显与高脂血症和高三酰甘油血症相关。虽然血脂异常对预后没有显著影响,但本研究首次将脂质与DLBCL的分子亚型相联系。