Optimization of a Series of Novel, Potent and Selective Macrocyclic SYK Inhibitors
Neil P. Grimster,Lakshmaiah Gingipalli,Amber Balazs,Bernard Barlaam,Scott Boiko,Scott Boyd,Hannah Dry,Frederick W. Goldberg, Tim Ikeda,Tony Johnson,Sameer Kawatkar,Paul Kemmitt,Scott Lamont,Olivier Lorthioir,Adelphe Mfuh,Joe Patel,Andy Pike,Jon Read,Romulo Romero,Ujjal Sarkar,Li Sha,Iain Simpson,Kun Song,Qibin Su,Haixia Wang,David Watson,Allan Wu, Troy E. Zehnder,XiaoLan Zheng, Shaolu Li, Zhiqiang Dong,Dejian Yang, Yanwei Song,Peng Wang, Xuemei Liu,James E. Dowling,Scott D. Edmondson Bioorganic & Medicinal Chemistry Letters（2023）
Key words
SYK,Kinase,Macrocycle,DLBCL
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