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    • 无功能垂体腺瘤的垂体相关转录因子表达与临床特征分析

    TANG Xiao-shuang,ZHANG Xiao-qing,YIN Hua-chun,ZHENG Xin,LI Song,YANG Hui

    Chinese Journal of Clinical Neurosurgery（2021）

    军医大学第二附属医院

    Cited 0|Views9
    Abstract
    目的 探讨垂体相关转录因子在无功能垂体腺瘤中的表达情况及其临床意义.方法 收集2013～2019年手术切除的无功能垂体腺瘤组织151例,采用组织芯片技术检测5个垂体相关转录因子(Pit-1、SF-1、GATA2、Tpit、ERα)的表达.结果 5个转录因子均阴性36例,Pit-1阳性91例,SF-1阳性11例,GATA2阳性9例,ERα阳性4例;生长激素(GH)细胞腺瘤53例,多激素细胞腺瘤42例,零细胞腺瘤36例,促性腺激素(GnH)细胞腺瘤11例,促甲状腺激素(TSH)细胞腺瘤9例,各类无功能垂体腺瘤病人的年龄和Ki-67指数无统计学差异(P＞0.05),TSH细胞腺瘤体积最小、侵袭性比例最低(P＜0.05),多激素细胞腺瘤、GnH细胞腺瘤和零细胞腺瘤体积较大(P＜0.05),零细胞腺瘤P53阳性率最低(P＜0.05).5个转录因子阳性表达以40～59岁病人多见(P＜0.05);Tpit阳性表达以男性多见(P＜0.05),其余4个转录因子以女性多见(P＜0.05).Pit-1阳性病人血清GH、TSH水平明显增高(P＜0.01),ERa阳性病人血清泌乳素水平明显增高(P＜0.05),GATA2阳性病人血清TSH水平明显增高(P＜0.01),血清促肾上腺皮质激素水平与5个转录因子表达水平无明显关系(P＞0.05).结论 垂体相关转录因子可以为临床诊断无功能垂体腺瘤提供新依据,而且其阳性表达与无功能垂体腺瘤病人的临床特征有密切联系.
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    【要点】：研究垂体相关转录因子在无功能垂体腺瘤中的表达，发现其与患者临床特征密切相关，为临床诊断提供新依据。
    

    【方法】：利用组织芯片技术检测5个垂体相关转录因子在151例无功能垂体腺瘤组织中的表达情况。
    

    【实验】：实验收集了2013至2019年手术切除的151例无功能垂体腺瘤组织，使用组织芯片技术检测Pit-1、SF-1、GATA2、Tpit、ERα等转录因子的表达，分析了不同类型腺瘤的年龄、Ki-67指数、腺瘤体积、侵袭性比例和P53阳性率等临床特征。