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Use of the Dtag System in Vivo to Degrade CDK2 and CDK5 in Adult Mice and Explore Potential Safety Liabilities

Paul Yenerall,Tae Sung, Kiran Palyada,Jessie Qian,Seda Arat,Steven W. Kumpf, Shih-Wen Wang,Kathleen Biddle, Carlos Esparza, Stephanie Chang,Wesley Scott,Walter Collette,Taylor-Symon Winrow, Tim Affolter,Norimitsu Shirai,Stephane Thibault, Julia Wang, Ling Liu, Mary Bauchmann, Jessica Frey, Stefanus Steyn,Aida Sacaan,Allison Vitsky,Youngwook Ahn, Tom Paul, Lawrence Lum,Jon Oyer, Amy Yang,Wenyue Hu

TOXICOLOGICAL SCIENCES（2023）

Cited 4|Views4
Key words
CDK2,CDK5,degradation,PROTAC,toxicity,mice
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