Putative Malignant Hyperthermia Mutation CaV1.1-R174W is Insufficient to Trigger a Fulminant Response to Halothane or Confer Heat Stress Intolerance.

Wei Feng,Jose R. Lopez,Shane Antrobus,Jing Zheng,Arkady Uryash,Yao Dong,Donald Beqollari,Roger A. Bannister,Philip M. Hopkins,Kurt G. Beam,Paul D. Allen,Isaac. N. Pessah

JOURNAL OF BIOLOGICAL CHEMISTRY（2023）

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Key words

malignant hyperthermia susceptibility,heat stress intolerance,voltage-activated Ca2+ channels,ryanodine receptor,TRPC3/6,knock-in mouse,muscle diseases

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