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SF3B1 Hotspot Mutations Confer Sensitivity to PARP Inhibition by Eliciting a Defective Replication Stress Response

Philip Bland,Harry Saville,Patty T. Wai,Lucinda Curnow,Gareth Muirhead,Jadwiga Nieminuszczy,Nivedita Ravindran, Marie Beatrix John,Somaieh Hedayat,Holly E. Barker,James Wright,Lu Yu,Ioanna Mavrommati,Abigail Read,Barrie Peck,Mark Allen,Patrycja Gazinska,Helen N. Pemberton,Aditi Gulati,Sarah Nash,Farzana Noor,Naomi Guppy,Ioannis Roxanis,Guy Pratt,Ceri Oldreive,Tatjana Stankovic,Samantha Barlow,Helen Kalirai,Sarah E. Coupland,Ronan Broderick,Samar Alsafadi,Alexandre Houy,Marc-Henri Stern,Stephen Pettit,Jyoti S. Choudhary,Syed Haider,Wojciech Niedzwiedz,Christopher J. Lord,Rachael Natrajan

Nature Genetics（2023）

Cited 17|Views49
Key words
Chronic lymphocytic leukaemia,Eye cancer,Genomic analysis,Personalized medicine,Transcriptomics,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics
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