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    • 骨形成蛋白7在ESCC中的表达及功能初步探究

    Sun Mengfei, Huang Hongfang, Dong Yuhang, Zhang Huakun, Zhou Ziru, Sun Qi,Guan Wenyan,Zhao Linyue,Cui Xiaobin,Chen Yunzhao,Li Feng

    Acta Universitatis Medicinalis Anhui（2023）

    石河子大学

    Cited 0|Views8
    Abstract
    目的 分析骨形成蛋白 7(BMP7)在食管鳞癌(ES-CC)中的表达和免疫浸润水平.方法 在 274 例 ESCC及242 例正常组织中应用免疫组织化学的形式验证BMP7 的水平,探索其表达差异与ESCC患者生存周期及临床病理特征间的联系,并且建立 BMP7 过表达质粒转染 ESCC 细胞系,借助CCK-8、Clone、Transwell检验BMP7 对ESCC细胞生物学行为的作用.结果 BMP7 在正常组织中表达高于ES-CC(P<0.001),BMP7 的表达与患者分化程度(P =0.006)和 TNM 分期(P<0.001)相关,且BMP7 高表达患者生存期超过 BMP7 低的患者(P =0.041),CCK-8、Clone实验表明过表达BMP7 组细胞增殖效果低于对照组,Transwell实验表明过表达BMP7 组细胞侵袭迁移能力小于对照组.免疫浸润结果显示BMP7 与巨噬细胞呈正相关(P =0.008),与γ-δT细胞呈负相关(P =0.028).结论 BMP7 在ESCC中低表达且与患者不良预后和免疫浸润水平相关.
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    Key words
    esophageal squamous cell carcinoma,BMP7,immunity,prognosis
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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